Inhibition of automatic responses controlled by the medulla, such as breathing or cardiac function. Male sex hormone responsible for the development of male characteristics. Absorption of drug (substance) through the skin, usually associated with the application of drug-loaded patches. fda.gov July 9, 2015, Walker C. Are All Oral COX-2 Selective Inhibitors the Same? 0000004240 00000 n The enzymatic biotransformation of a drug into metabolites. Form of general anesthesia in which patients do not appear to be unconscious. Percentage of the drug dosage that is absorbed. 0000041698 00000 n Steroid produced within the adrenal cortex that directly influences sodium and potassium metabolism. Drug that abolishes the response to pain by depressing the central nervous system (CNS) and producing loss of consciousness. PHARMACOLOGY Dr. Armen Varosyan Associate Professor, DEAA, PhD Department of Anaesthesiology and Intensive Care Yerevan State Medical University Yerevan, Armenia ESA On-Line Assessment (OLA) Subcommittee Chairperson. A fat formed by three fatty acids into one molecule that supplies energy to muscle cells. ���-��-��V��U/���ی63��@��&y*�d+|W|�8�R�8�t��mr �4 �Jޢx�q+�v[�X��&�n�%D���ȱ�c��� P�ɪTS��n� �C�i�f8���k~?U㻁�Ĝ�^Xu��c����*0�4� :ԅv��Fs�VS��1�c���p�����ݖp�[:�*�cĸ? Muscle spasms, facial grimacing, and other involuntary movements and postures. Protection from viral reinfection in the form of antibodies produced during an infection (active) or produced after exposure to a vaccine (passive). Route of drug administration that does not involve the gastrointestinal (GI) tract. Origin of the pain is in a different location than where the individual feels the pain. Effect in which a great volume of acid is secreted by the stomach in response to the reduced acid environment caused by antacid neutralization. Part of the brainstem that serves as a relay station for nerve fibers traveling to other brain areas; also involved in sensory and motor functions. Undesirable drug effect that implies drug poisoning; can be very harmful or life-threatening. COX-2 inhibitors target pain and inflammation with fewer gastrointestinal side effects. Process by which the blood changes from a liquid to a solid “plug” as a reaction to local tissue injury; normal blood clot formation. Distortion of sensory perception; usually associated with the use of LSD. Excess fluid in the space between the tissues lining the abdomen and abdominal organs (the peritoneal cavity), usually associated with organ failure. 0000024104 00000 n 0000002603 00000 n When the action resulting from a combination of drugs is greater than the sum of their individual drug effects. Infection in the blood caused by the yeast. Cell that synthesizes and releases hydrochloric acid (HCl) into the stomach lumen. Condition associated with a decrease in thyroid function, caused by removal of thyroid tissue or loss of tissue function because of damage to cells; also associated with subcutaneous edema and slowed metabolism. Bacterial enzymes that inactivate betalactam antibiotics; bacterial enzymes that inactivate penicillin and cephalosporin antibiotics. Condition in which very small amounts of urine are produced. Space (synapse) between a motor nerve ending and a skeletal muscle membrane that contains acetylcholine (ACH) receptors. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526006/, Brune K, Patrignani P. New insights into the use of currently available non-steroidal anti-inflammatory drugs. Naturally occurring within the body; originating or produced within an organism, tissue, or cell. Toxic syndrome associated with the use of antipsychotic drugs. The pressure of the blood within the arteries; depends primarily on the cardiac output and the peripheral resistance. Bursting open or separation of a wound, usually along sutured line. Type of bacteria that cause disease; a microorganism that causes disease. Refers to norepinephrine, epinephrine, and other sympathomimetic compounds that possess the catechol structure. A metabolite of muscle metabolism that is excreted in the urine in proportion to renal function. shedding of endometrial tissue with accompanying bleeding; the first day of the menstrual cycle. Process in which the nephrons produce and release substances (ions, acids, and bases) that facilitate sodium ion reabsorption and maintain acid-base balance. Drug usually administered IV that stops a convulsive seizure. Drug effect other than the therapeutic effect that is usually undesirable but not harmful. Common measure of solution concentration; refers to grams of solute per 100 ml of solution. Open sore in the mucous membranes or mucosal linings of the body. Drug that blocks both beta-1 and beta-2 adrenergic receptors. 0000073161 00000 n Name that defines the chemical composition of a drug. Enables another hormone to fully function. Substance that is soothing to mucous membranes or skin. 0000027854 00000 n Please enter username and password bellow! Potent vasoconstrictor that also stimulates release of aldosterone and antidiuretic hormone. 0000003139 00000 n When drugs (substances) produce the same intensity or spectrum of activity; usually, the absolute amount of drug (for example, 5, 10 mg) that produces the response is different for each substance, but the response generated is the same. FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes. trailer An abnormal widening or ballooning of a portion of an artery due to weakness in the wall of the blood vessel. Partially digested food and gastric secretions that moves into the duodenum from the stomach by peristalsis. One of the forms of cholesterol transported in the blood with lipoprotein; known as “bad” cholesterol. In: StatPearls [Internet]. Produces adequate anesthesia with minimal side effects. Ability to keep a patient safely in Stage III of anesthesia.
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